Title: Immunoprophylaxis and immunotherapy of Staphylococcus epidermidis infections: challenges and prospects
Authors: Van Mellaert, Lieve ×
Shahrooei, Mohammad
Hofmans, Dorien
Van Eldere, Johan #
Issue Date: Mar-2012
Publisher: Expert Reviews Ltd.
Series Title: Expert Review of Vaccines vol:11 issue:3 pages:319-334
Abstract: Previously considered a human commensal, Staphylococcus epidermidis is a frequent cause of nosocomial infections and the most common cause of device-related infections. Because the expression of toxins and other obvious virulence factors is less in S. epidermidis, the biofilm-forming capacity is its major virulence factor. Biofilm growth is characterized by high resistance to antimicrobial agents and host immune responses, making biofilm eradication tremendously difficult. The increasing prevalence of multidrug-resistant S. epidermidis strains additionally hampers antimicrobial therapy. Therefore, immunoprophylaxis and immunotherapy targeting factors expressed at some point in biofilm formation might offer new tools to combat S. epidermidis infections. So far, a limited number of targets have been examined for their immunotherapeutic potential. In this review, we focus on the already tested and possible targets for vaccine development, discuss the accompanying challenges and speculate on future possibilities with respect to immunotherapeutic solutions to deal with S. epidermidis infections.
ISSN: 1476-0584
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Molecular Bacteriology (Rega Institute)
Laboratory of Clinical Bacteriology and Mycology
× corresponding author
# (joint) last author

Files in This Item:
File Description Status SizeFormat
2012186.pdf Published 788KbAdobe PDFView/Open Request a copy

These files are only available to some KU Leuven Association staff members


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science