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Title: Mucorales-specific T cells emerge in the course of invasive mucormycosis and may be used as a surrogate diagnostic marker in high-risk patients
Authors: Potenza, Leonardo ×
Vallerini, Daniela
Barozzi, Patrizia
Riva, Giovanni
Forghieri, Fabio
Zanetti, Eleonora
Quadrelli, Chiara
Candoni, Anna
Maertens, Johan
Rossi, Giulio
Morselli, Monica
Codeluppi, Mauro
Paolini, Ambra
Maccaferri, Monica
Del Giovane, Cinzia
D'Amico, Roberto
Rumpianesi, Fabio
Pecorari, Monica
Cavalleri, Francesca
Marasca, Roberto
Narni, Franco
Luppi, Mario #
Issue Date: Nov-2011
Publisher: W.B. Saunders
Series Title: Blood vol:118 issue:20 pages:5416-5419
Abstract: Mucorales-specific T cells were investigated in 28 hematologic patients during the course of their treatment. Three developed proven invasive mucormycosis (IM), 17 had infections of known origin but other than IM, and 8 never had fever during the period of observation. Mucorales-specific T cells could be detected only in patients with IM, both at diagnosis and throughout the entire course of the IM, but neither before nor for long after resolution of the infection. Such T cells predominantly produced IL-4, IFN-gamma, IL-10, and to a lesser extent IL-17 and belonged to either CD4(+) or CD8(+) subsets. The specific T cells that produced IFN-gamma were able to directly induce damage to Mucorales hyphae. None of the 25 patients without IM had Mucorales-specific T cells. Specific T cells contribute to human immune responses against fungi of the order Mucorales and could be evaluated as a surrogate diagnostic marker of IM. (Blood. 2011;118(20):5416-5419)
ISSN: 0006-4971
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Embryo and Stemcells (-)
× corresponding author
# (joint) last author

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