Title: T lymphocyte-endothelial cell interactions
Authors: Choi, J *
Enis, DR *
Koh, Kian *
Shiao, SL *
Pober, JS # ×
Issue Date: Apr-2004
Publisher: Annual Reviews Inc.
Series Title: Annual Review of Immunology vol:22 pages:683-709
Abstract: Human vascular endothelial cells (EC) basally display class I and 11 MHC-peptide complexes on their surface and come in regular contact with circulating T cells. We propose that EC present microbial antigens to memory T cells as a mechanism of immune surveillance. Activated T cells, in turn, provide both soluble and contact-dependant signals to modulate normal EC functions, including formation and remodeling of blood vessels, regulation of blood flow, regulation of blood fluidity, maintenance of permselectivity, recruitment of inflammatory leukocytes, and antigen presentation leading to activation of T cells. T cell interactions with vascular EC are thus bidirectional and link the immune and circulatory systems.
ISSN: 0732-0582
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Embryo and Stemcells (-)
* (joint) first author
× corresponding author
# (joint) last author

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