Title: Human allograft arterial injury is ameliorated by sirolimus and cyclosporine and correlates with suppression of interferon-gamma
Authors: Yi, T
Cuchara, L
Wang, YN
Koh, Kian
Ranjbaran, H
Tellides, G
Pober, JS
Lorber, MI # ×
Issue Date: 27-Feb-2006
Publisher: Lippincott Williams & Wilkins
Series Title: Transplantation vol:81 issue:4 pages:559-566
Abstract: Background. Chronic allograft dysfunction may result from arterial injury, manifest as transplant arteriosclerosis (TA). This represents an important factor limiting long-term Outcomes after heart and kidney transplantation; a relationship between acute allograft arterial injury and TA has been suggested. We have used SCID/bg mice bearing transplanted human artery, inoculated with allogeneic human PBMC to study arteriopathy in human vessels. Earlier work demonstrated arteriopathy similar to that observed clinically, and identified interferon-gamma as a mediator of the process. This study evaluated whether sirolimus (SRL), with cyclosporine A (CsA) or alone, affects TA, and examined possible mechanisms of action.
ISSN: 0041-1337
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Embryo and Stemcells (-)
× corresponding author
# (joint) last author

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