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Title: Transcription factor Efg1 contributes to tolerance of Candida albicans biofilms against antifungal agents in vitro and in vivo
Authors: Bink, Anna ×
Govaert, Gilmer
Vandenbosch, D.
Kucharikova, S.
Coenye, T.
Nelis, Hans
Van Dijck, Patrick
Cammue, Bruno
Thevissen, Karin #
Issue Date: Jun-2012
Publisher: Churchill Livingstone
Series Title: Journal of Medical Microbiology vol:61 issue:6 pages:813-819
Abstract: We investigated the molecular basis of the tolerance of Candida albicans biofilms to the model compound miconazole, and translated these data to other antifungals. Sessile cells of C. albicans Δefg1, lacking the transcription factor Efg1, showed increased susceptibility to miconazole, amphotericin B and caspofungin, whereas these sessile cells were equally resistant to fluconazole. The increased miconazole sensitivity was at least partly due to an increased accumulation of miconazole in the cells as compared to wild type or reintegrant Δefg1(EFG1) sessile cells. By using a rat biofilm model, we further confirmed the role of Efg1 in miconazole tolerance of in vivo grown C. albicans biofilms.
ISSN: 0022-2615
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Centre of Microbial and Plant Genetics
Faculty of Medicine - miscellaneous
Molecular Microbiology and Biotechnology Section - miscellaneous
× corresponding author
# (joint) last author

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