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Title: An aberrant cerebellar development in mice lacking matrix metalloproteinase-3
Authors: Van Hove, Inge ×
Verslegers, Mieke
Buyens, Tom
Delorme, Nathalie
Lemmens, Kim
Stroobants, Stijn
Gantois, Ilse
D'Hooge, Rudi
Moons, Lieve #
Issue Date: Feb-2012
Publisher: Humana Press
Series Title: Molecular Neurobiology vol:45 issue:1 pages:17-29
Abstract: Cell-cell and cell-matrix interactions are necessary for neuronal patterning and brain wiring during development. Matrix metalloproteinases (MMPs) are proteolytic enzymes capable of remodelling the pericellular environment and regulating signaling pathways through cleavage of a large degradome. MMPs have been suggested to affect cerebellar development, but the specific role of different MMPs in cerebellar morphogenesis remains unclear. Here, we report a role for MMP-3 in the histogenesis of the mouse cerebellar cortex. MMP-3 expression peaks during the second week of postnatal cerebellar development and is most prominently observed in Purkinje cells (PCs). In MMP-3 deficient (MMP-3(-/-)) mice, a protracted granule cell (GC) tangential migration and a delayed GC radial migration results in a thicker and persistent external granular layer, a retarded arrival of GCs in the inner granular layer, and a delayed GABAergic interneuron migration. Importantly, these neuronal migration anomalies, as well as the consequent disturbed synaptogenesis on PCs, seem to be caused by an abnormal PC dendritogenesis, which results in reduced PC dendritic trees in the adult cerebellum. Of note, these developmental and adult cerebellar defects might contribute to the aberrant motor phenotype observed in MMP-3(-/-) mice and suggest an involvement of MMP-3 in mouse cerebellar development.
ISSN: 0893-7648
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Animal Physiology and Neurobiology Section - miscellaneous
Department of Biology - miscellaneous
Research Group Neural Circuit Development and Regeneration (-)
Biological Psychology
× corresponding author
# (joint) last author

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