Synthesis of CD-ring modified 1alpha,25-dihydroxy vitamin D analogues:E-ring analogues

Sabbe, K; D'Hallewyn, C; De Clercq, P; Vandewalle, M; Bouillon, Roger; Verstuyf, Annemieke

doi:10.1016/0960-894X(96)00300-9

Synthesis of CD-ring modified 1alpha,25-dihydroxy vitamin D analogues:E-ring analogues

Author:

Sabbe, K

D'Hallewyn, C ; De Clercq, P ; Vandewalle, M ; Bouillon, Roger ; Verstuyf, Annemieke

Keywords:

Science & Technology, Life Sciences & Biomedicine, Physical Sciences, Chemistry, Medicinal, Chemistry, Organic, Pharmacology & Pharmacy, Chemistry, 0304 Medicinal and Biomolecular Chemistry, 0305 Organic Chemistry, 1115 Pharmacology and Pharmaceutical Sciences, Medicinal & Biomolecular Chemistry, 3404 Medicinal and biomolecular chemistry, 3405 Organic chemistry

Abstract:

Vitamin D analogues, characterized by the absence of both C- and D-rings and by the presence of a five-membered ring formed by connecting C12 and C21 (E-ring analogues) are described.