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Title: Pressure effect on the hydration properties of poly(N-isopropylacrylamide) in aqueous solution studied by FTIR spectroscopy
Authors: Meersman, Filip ×
Wang, J
Wu, YQ
Heremans, Karel #
Issue Date: Jan-2005
Publisher: Amer chemical soc
Series Title: Macromolecules vol:38 issue:21 pages:8923-8928
Abstract: The hydration properties of poly(N-isopropylacrylamide) in aqueous solution were investigated by Fourier transform infrared spectroscopy as a function of high hydrostatic pressure and compared to the thermally induced changes. We show that although both pressure and temperature induce a phase separation the underlying mechanisms are fundamentally different. It is well documented that increasing the temperature above the lower critical solution temperature causes a dehydration of the hydrophilic and hydrophobic moieties. By contrast, high pressure enhances the hydration of the hydrophilic amide group. Moreover, pressure strengthens the weak C-H center dot center dot center dot O hydrogen bonds between the hydrophobic alkyl groups and water, although a reorganization of the water network around the hydrophobic groups occurs during the phase separation. From this it is concluded that PNiPA remains in a coillike state at high pressure. In addition, we suggest that PNiPA is a good model for the study of the hydration properties of proteins.
ISSN: 0024-9297
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Imaging and Photonics
ESAT - PSI, Processing Speech and Images
Biochemistry, Molecular and Structural Biology Section
× corresponding author
# (joint) last author

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