Detection of drug resistance mutations at low plasma HIV-1 RNA load in a European multicentre cohort study
Prosperi, Mattia C. F × Mackie, Nicola Di Giambenedetto, Simona Zazzi, Maurizio Camacho, Ricardo Fanti, Iuri Torti, Carlo Soennerborg, Anders Kaiser, Rolf Codoner, Francisco M Van Laethem, Kristel Bansi, Loveleen van de Vijver, David A. M. C Geretti, Anna Maria De Luca, Andrea #
Oxford University Press
The Journal of Antimicrobial Chemotherapy vol:66 issue:8 pages:1886-1896
Background and objectives: Guidelines indicate a plasma HIV-1 RNA load of 500-1000 copies/mL as the minimal threshold for antiretroviral drug resistance testing. Resistance testing at lower viral load levels may be useful to guide timely treatment switches, although data on the clinical utility of this remain limited. We report here the influence of viral load levels on the probability of detecting drug resistance mutations (DRMs) and other mutations by routine genotypic testing in a large multicentre European cohort, with a focus on tests performed at a viral load <1000 copies/mL.