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Title: Detection of drug resistance mutations at low plasma HIV-1 RNA load in a European multicentre cohort study
Authors: Prosperi, Mattia C. F ×
Mackie, Nicola
Di Giambenedetto, Simona
Zazzi, Maurizio
Camacho, Ricardo
Fanti, Iuri
Torti, Carlo
Soennerborg, Anders
Kaiser, Rolf
Codoner, Francisco M
Van Laethem, Kristel
Bansi, Loveleen
van de Vijver, David A. M. C
Geretti, Anna Maria
De Luca, Andrea #
Issue Date: Aug-2011
Publisher: Oxford University Press
Series Title: The Journal of Antimicrobial Chemotherapy vol:66 issue:8 pages:1886-1896
Abstract: Background and objectives: Guidelines indicate a plasma HIV-1 RNA load of 500-1000 copies/mL as the minimal threshold for antiretroviral drug resistance testing. Resistance testing at lower viral load levels may be useful to guide timely treatment switches, although data on the clinical utility of this remain limited. We report here the influence of viral load levels on the probability of detecting drug resistance mutations (DRMs) and other mutations by routine genotypic testing in a large multicentre European cohort, with a focus on tests performed at a viral load <1000 copies/mL.
ISSN: 0305-7453
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Clinical and Epidemiological Virology (Rega Institute)
× corresponding author
# (joint) last author

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