Title: Synthesis of 5-Substituted 2'-Deoxyuridine-5'- Phosphonate Analogues and Evaluation of their Antiviral Activity
Authors: Van Poecke, Sara ×
Sinnaeve, Davy
Martins, José C
Balzarini, Jan
Van Calenbergh, Serge #
Issue Date: Mar-2012
Publisher: Marcel Dekker
Series Title: Nucleosides, Nucleotides & Nucleic Acids vol:31 issue:3 pages:256-72
Abstract: A small series of 5-(hetero)aryl-modified nucleoside phosphonates was synthesized via an 8-step procedure including a Wittig reaction and Suzuki-Miyaura coupling. An unanticipated anomerization during phosphonate deprotection allowed us to isolate both anomers of the 5-substituted 2'-deoxy-uridine phosphonates and assess their antiviral activity against a broad panel of viruses.
ISSN: 1525-7770
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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