Follicle stimulating hormone receptor G-29A, 919A>G, 2039A>G polymorphism and the risk of male infertility : a meta-analysis

Wu, W; Cai, H; Sun, Hong; Lu, J; Zhao, D; Qin, Y; Han, X; Niu, X; Lu, C; Xia, Y; Wang, S; De Moor, Bart; Marchal, Kathleen; Wang, X

doi:10.1016/j.gene.2012.02.023

Follicle stimulating hormone receptor G-29A, 919A>G, 2039A>G polymorphism and the risk of male infertility : a meta-analysis

Author:

Wu, W

Cai, H ; Sun, Hong ; Lu, J ; Zhao, D ; Qin, Y ; Han, X ; Niu, X ; Lu, C ; Xia, Y ; Wang, S ; De Moor, Bart ; Marchal, Kathleen ; Wang, X

Keywords:

SISTA, Science & Technology, Life Sciences & Biomedicine, Genetics & Heredity, FSHR, Male infertility, Meta-analysis, Polymorphism, SINGLE-NUCLEOTIDE POLYMORPHISMS, FSH RECEPTOR, GENE POLYMORPHISMS, POLG, MEN, SPERMATOGENESIS, SUSCEPTIBILITY, IDENTIFICATION, ASSOCIATION, COMPLEXITY, Genetic Predisposition to Disease, Humans, Infertility, Male, Male, Polymorphism, Genetic, Polymorphism, Single Nucleotide, Receptors, FSH, Risk, 0604 Genetics, 0606 Physiology, 1108 Medical Microbiology, Developmental Biology, 3101 Biochemistry and cell biology, 3102 Bioinformatics and computational biology, 3105 Genetics

Abstract:

Studies of the relationship between male infertility and polymorphisms in the regions of FSHR G-29A (rs1394205), 919A>G (Thr(307)Ala, rs6165) and 2039A>G (Asn(680)Ser, rs6166) have reported inconsistent results. To assess the association between them, a meta-analysis was conducted. PubMed and CBMdisc literature search were conducted to identify all eligible studies investigating such a relationship. The pooled ORs were performed for co-dominant model, dominant model and recessive model in FSHR G-29A, Thr(307)Ala and Asn(680)Ser respectively to assess the strength of association. A total of 1644 male infertility cases and 1748 controls were collected from seven case-control studies. In the overall analysis, no significant association between the three polymorphisms and risk of male infertility was observed. Stratified analysis showed that there were no significantly increased risks of azoospermia and oligoasthenoteratozoospermia (OAT) in any of the genetic models. This meta-analysis supports that FSHR G-29A, Thr(307)Ala and Asn(680)Ser polymorphisms may not be capable of causing male infertility susceptibility.