Title: Intercellular adhesion molecule-1 clusters during osteoclastogenesis
Authors: Bloemen, Veerle ×
de Vries, Teun J
Schoenmaker, Ton
Everts, Vincent #
Issue Date: Aug-2009
Publisher: Academic Press
Series Title: Biochemical and Biophysical Research Communications vol:385 issue:4 pages:640-645
Abstract: Adhesion between osteoblasts and osteoclast precursors is established via an interaction involving intercellular adhesion molecule-1 (ICAM-1) on osteoblasts and leukocyte function-associated antigen-1 (LFA-1) on osteoclast precursors. The latter cells also express ICAM-1, but little is known about the expression over time and its possible role during osteoclastogenesis. In the present Study we investigated the expression of ICAM-1 on both human osteoblast-like cells and osteoclast precursors in a co-culture. The protein expression on osteoclast precursors strongly increased whereas the osteoblast-like cells became ICAM-1 negative. Interestingly, ICAM-1 on osteoclast precursors manifested as Clusters which localized at the baso-lateral membrane. Furthermore, clustered ICAM-1 was associated with F-actin and remained present for several days. Our data Suggest that osteoblastic ICAM-1 is mainly involved in the initial adhesion of osteoclast precursors whereas Clustered ICAM-1 on osteoclast precursors and its association with F-actin suggest an involvement in cell movement at a later stage. (C) 2009 Elsevier Inc. All rights reserved.
ISSN: 0006-291X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Materials Engineering - miscellaneous
Materials Technology TC, Campus Group T Leuven
Technologiecluster Materialentechnologie
× corresponding author
# (joint) last author

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