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Title: Cytokinesis remnants define first neuronal asymmetry in vivo
Authors: Pollarolo, Giulia ×
Schulz, Joachim
Munck, Sebastian
Dotti, Carlos #
Issue Date: Dec-2011
Publisher: Nature America Inc.
Series Title: Nature Neuroscience vol:14 issue:12 pages:1525-33
Article number: 10.1038/nn.2976
Abstract: Polarization of a neuron begins with the appearance of the first neurite, thus defining the ultimate growth axis. Unlike late occurring polarity events (such as axonal growth), very little is known about this fundamental process. We show here that, in Drosophila melanogaster neurons in vivo, the first membrane deformation occurred 3.6 min after precursor division. Clustering of adhesion complex components (Bazooka (Par-3), cadherin-catenin) marked this place by 2.8 min after division; the upstream phosphatidylinositol 4,5-bisphosphate, by 0.7 min after division; and the furrow components RhoA and Aurora kinase, from the time of cytokinesis. Local DE-cadherin inactivation prevented sprout formation, whereas perturbation of division orientation did not alter polarization from the cytokinesis pole. This is, to our knowledge, the first molecular study of initial neuronal polarization in vivo. The mechanisms of polarization seem to be defined at the precursor stage.
URI: 
ISSN: 1097-6256
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
Laboratory of Neuronal Differentiation
× corresponding author
# (joint) last author

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