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Title: Human plasma glycome in attention-deficit hyperactivity disorder and autism spectrum disorders
Authors: Pivac, Nela ×
Knezević, Ana
Gornik, Olga
Pucić, Maja
Igl, Wilmar
Peeters, Hilde
Crepel, An
Steyaert, Jean
Novokmet, Mislav
Redzić, Irma
Nikolac, Matea
Hercigonja, Vesna Novković
Curković, Katarina Dodig
Curković, Mario
Nedić, Gordana
Muck-Seler, Dorotea
Borovecki, Fran
Rudan, Igor
Lauc, Gordan #
Issue Date: Jan-2011
Publisher: American Society for Biochemistry and Molecular Biology
Series Title: Molecular & Cellular Proteomics vol:10 issue:1 pages:M110.004200
Article number: M110.004200
Abstract: Over a half of all proteins are glycosylated, and their proper glycosylation is essential for normal function. Unfortunately, because of structural complexity of nonlinear branched glycans and the absence of genetic template for their synthesis, the knowledge about glycans is lagging significantly behind the knowledge about proteins or DNA. Using a recently developed quantitative high throughput glycan analysis method we quantified components of the plasma N-glycome in 99 children with attention-deficit hyperactivity disorder (ADHD), 81 child and 5 adults with autism spectrum disorder, and a total of 340 matching healthy controls. No changes in plasma glycome were found to associate with autism spectrum disorder, but several highly significant associations were observed with ADHD. Further structural analysis of plasma glycans revealed that ADHD is associated with increased antennary fucosylation of biantennary glycans and decreased levels of some complex glycans with three or four antennas. The design of this study prevented any functional conclusions about the observed associations, but specific differences in glycosylation appears to be strongly associated with ADHD and warrants further studies in this direction.
URI: 
ISSN: 1535-9476
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical Genetics
Department of Human Genetics - miscellaneous
Laboratory for Genetics of Human Development
Research Group Psychiatry
× corresponding author
# (joint) last author

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