Title: Complex genetic architecture of Drosophila aggressive behavior
Authors: Zwarts, Liesbeth ×
Magwire, Michael M
Carbone, Mary Anna
Versteven, Marijke
Herteleer, Liesbet
Anholt, Robert R. H
Callaerts, Patrick
Mackay, Trudy F. C #
Issue Date: Oct-2011
Publisher: National Academy of Sciences
Series Title: Proceedings of the National Academy of Sciences of the United States of America vol:108 issue:41 pages:17070-17075
Abstract: Epistasis and pleiotropy feature prominently in the genetic architecture of quantitative traits but are difficult to assess in outbred populations. We performed a diallel cross among coisogenic Drosophila P-element mutations associated with hyperaggressive behavior and showed extensive epistatic and pleiotropic effects on aggression, brain morphology, and genome-wide transcript abundance in head tissues. Epistatic interactions were often of greater magnitude than homozygous effects, and the topology of epistatic networks varied among these phenotypes. The transcriptional signatures of homozygous and double heterozygous genotypes derived from the six mutations imply a large mutational target for aggressive behavior and point to evolutionarily conserved genetic mechanisms and neural signaling pathways affecting this universal fitness trait.
ISSN: 0027-8424
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
Laboratory of Behavioral and Developmental Genetics
× corresponding author
# (joint) last author

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