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Title: Protein stability and dynamics in the pressure-temperature plane
Authors: Meersman, Filip ×
Smeller, L
Heremans, Karel #
Issue Date: Jan-2006
Publisher: Elsevier science bv
Series Title: Biochimica et biophysica acta-proteins and proteomics vol:1764 issue:3 pages:346-354
Abstract: The pressure-temperature stability diagram of proteins and the underlying assumptions of the elliptical shape of the diagram are discussed. Possible extensions, Such as aggregation and fibril formation, are considered. Ail important experimental observation is the extreme pressure stability of the mature fibrils. Molecular origins of the diagram in terms of models of the partial molar volume of a protein focus on cavities and hydration. Changes in thermal expansivity, compressibility and heat capacity in terms of fluctuations of the enthalpy and Volume change of the unfolding should also focus on these parameters. It is argued that the study of water-soluble polymers might further our understanding of the stability diagram. Whereas the role of water in protein behaviour is unquestioned, the role of cavities is less clear. (c) 2005 Elsevier B.V. All rights reserved.
URI: 
ISSN: 1570-9639
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Imaging and Photonics
Biochemistry, Molecular and Structural Biology Section
× corresponding author
# (joint) last author

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