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Title: Association of Left Ventricular Mass With the AGTR1 A1166C Polymorphism
Authors: Jin, Yu ×
Kuznetsova, Tatiana
Thijs, Lutgarde
Schmitz, Boris
Liu, Yanping
Asayama, Kei
Brand, Stefan-Martin
Heymans, Stephane
Brand, Eva
Fagard, Robert
Staessen, Jan A #
Issue Date: Apr-2012
Publisher: Elsevier
Series Title: American Journal of Hypertension vol:25 issue:4 pages:472-478
Article number: 10.1038/ajh.2011.244
Abstract: BackgroundThe A1166C polymorphism is located within the microRNA-155 binding site of the human angiotensin II (Ang II) type-1 receptor (AGTR1) gene. The C allele interferes with the base-pairing complementariness between AGTR1 mRNA and microRNA-155 and thereby increases AGTR1 protein expression in vitro. We hypothesized that left ventricular (LV) mass is associated with the AGTR1 A1166C polymorphism.MethodsAmong 708 individuals (mean age, 49.4 years; 51.8% women) randomly recruited in a white European population, we measured LV structure by two-dimensional guided M-mode echocardiography, the AGTR1 A1166C polymorphism and the 24-h urinary aldosterone. We applied a mixed model to assess phenotype-genotype associations while adjusting for covariables and accounting for relatedness.ResultsThe AA (49.1%), AC (42.8%), and CC (8.1%) genotypes were in Hardy-Weinberg equilibrium. Using a recessive model, CC homozygotes compared to A-allele carriers showed significant increases (P < 0.021) in LV mass index (+5.78 ± 2.25 g/m(2)), mean wall thickness (MWT) (+0.48 ± 0.15 mm), interventricular septum (IVS) (+0.60 ± 0.18 mm) and posterior wall thickness (PWT) (+0.34 ± 0.15 mm), but lower 24-h urinary aldosterone excretion (geometric mean, 22.4 vs. 19.0 nmol; P = 0.050). Sensitivity analyses in 552 participants untreated for hypertension were confirmatory.ConclusionsLV mass index is associated with the AGTR1 A1166C polymorphism. Further research should clarify to what extent this association might be mediated via different expression of AGTR1 as modulated by microRNA-155American Journal of Hypertension 2012; doi:10.1038/ajh.2011.244.
ISSN: 0895-7061
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Hypertension and Cardiovascular Epidemiology
Molecular and Vascular Biology
× corresponding author
# (joint) last author

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