Title: Tissue Doppler indexes of left ventricular systolic function in relation to the pulsatile and steady components of blood pressure in a general population
Authors: Sakiewicz, Wojciech
Kuznetsova, Tatiana ×
Kloch-Badelek, Malgorzata
D'hooge, Jan
Ryabikov, Andrew
Kunicka, Katarzyna
Swierblewska, Ewa
Thijs, Lutgarde
Jin, Yu
Loster, Magdalena
Malyutina, Sofia
Stolarz-Skrzypek, Katarzyna
Kawecka-Jaszcz, Kalina
Narkiewicz, Krzysztof
Staessen, Jan A
on behalf of the European Project On Genes in Hypertension (EPOGH) Investigators #
Issue Date: Feb-2012
Publisher: Gower Medical Pub.
Series Title: Journal of Hypertension vol:30 issue:2 pages:403-410
Abstract: OBJECTIVES:: To our knowledge, no population study described the association of the radial and longitudinal components of left ventricular strain with blood pressure (BP) components in continuous analyses. We therefore investigated these associations in participants randomly recruited from the general population in the framework of the family-based European Project on Genes in Hypertension. METHODS:: In 334 participants (55.4% women; mean age, 43.6 year), using tissue Doppler imaging (TDI), we measured the end-systolic longitudinal strain (mean 20.9%) and peak systolic strain rate (1.29 s) from the basal portion of the left ventricular inferior and posterior free walls and radial stain (51.1%) and strain rate (3.40 s) of the left ventricular posterior wall. Models included in addition to covariables and confounders both SBP and DBP or both pulse pressure (PP) and mean arterial pressure (MAP). Effect sizes were expressed per 1-SD increase in BP. RESULTS:: Longitudinal strain (-0.62%; P = 0.04 and -0.64%; P = 0.007), but not strain rate, decreased with DBP and MAP. Radial strain (4.0 and -3.4%; P ≤ 0.001) and strain rate (0.38 and -0.18 s; P ≤ 0.04) independently increased with SBP and decreased with DBP. Accordingly, radial strain (2.9%; P < 0.0001) and strain rate (0.22 s; P = 0.0005) increased with higher PP, but were not related to MAP. CONCLUSION:: In the general population, BP is an independent determinant of left ventricular systolic function as measured by TDI. Radial function increased with PP, the pulsatile BP component, whereas longitudinal function decreased with the steady component of BP as expressed by MAP or DBP.
ISSN: 0263-6352
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Hypertension and Cardiovascular Epidemiology
Cardiovascular Imaging and Dynamics
× corresponding author
# (joint) last author

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