Title: Azo polymers for colon-specific drug-delivery. 2. Influence of the type of azo polymer on the degradation by intestinal microflora
Authors: Van den Mooter, Guy ×
Samyn, Celest
Kinget, Renaat #
Issue Date: Aug-1993
Publisher: Elsevier science bv
Series Title: International journal of pharmaceutics vol:97 issue:1-3 pages:133-139
Abstract: Degradation by gastrointestinal microflora of different azo polymers was studied by performing permeability experiments on isolated films and solution viscosity measurements before and after incubation in Schaedler broth, inoculated with human feces. The investigated azo polymers were different in monomer composition (hydroxyethyl methacrylate/ methyl methacrylate ratio) and azo aromatic group (divinylazobenzene, N,N'-bis(methacryloylamino)azobenzene and N,N'-bis(methacryloyloxyethyloxycarbonylamino)azobenzene). The degradation of the azo polymers was strongly affected by the hydrophilicity of the polymers. The chain length of the azo aromatic groups, built into the azo polymers, seems to be of little influence on the degradation rate of the polymers.
ISSN: 0378-5173
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Drug Delivery and Disposition
Chemistry - miscellaneous
× corresponding author
# (joint) last author

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