International journal of pharmaceutics vol:97 issue:1-3 pages:133-139
Degradation by gastrointestinal microflora of different azo polymers was studied by performing permeability experiments on isolated films and solution viscosity measurements before and after incubation in Schaedler broth, inoculated with human feces. The investigated azo polymers were different in monomer composition (hydroxyethyl methacrylate/ methyl methacrylate ratio) and azo aromatic group (divinylazobenzene, N,N'-bis(methacryloylamino)azobenzene and N,N'-bis(methacryloyloxyethyloxycarbonylamino)azobenzene). The degradation of the azo polymers was strongly affected by the hydrophilicity of the polymers. The chain length of the azo aromatic groups, built into the azo polymers, seems to be of little influence on the degradation rate of the polymers.