Title: Air Pollution-Associated Procoagulant Changes: role of Circulating Microvesicles
Authors: Emmerechts, Jan ×
Jacobs, Lotte
Van kerckhoven, Soetkin
Loyen, Serena
Mathieu, Chantal
Fierens, F
Nemery, Benoit
Nawrot, T S
Hoylaerts, Marc #
Issue Date: 2012
Publisher: Blackwell Pub.
Series Title: Journal of Thrombosis and Haemostasis vol:10 pages:96-106
Article number: 10.1111/j.1538-7836.2011.04557.x
Abstract: Background: Epidemiological studies suggest an association between exposure to particulate matter (PM) in air pollution and risk of venous thromboembolism (VTE). Objectives: To investigate the underlying pathophysiological pathways linking PM exposure and VTE. Methods: We assessed potential associations between PM exposure and coagulation and inflammation parameters, including circulating microvesicles, in a group of 233 patients with diabetes. Results: The numbers of circulating blood platelet-derived and annexin V-binding microvesicles were inversely associated with the current levels of PM(2.5) or PM(10) , measured on the day of sampling. Recent past exposure to PM(10) , up to 1 week prior to blood sampling, estimated at the patients' residential addresses, was associated with elevated high-sensitivity C-reactive protein (CRP), leukocytes and fibrinogen, as well as with tissue factor-dependent procoagulant changes in thrombin generation assays. When longer windows of past exposure were considered, up to 1 year preceding blood sampling, procoagulant changes were evident from the strongly increased numbers of red blood cell-derived circulating microvesicles and annexin V-binding microvesicles, but they no longer associated with tissue factor. Past PM exposure was never associated with activated partial thromboplastin time (aPTT), prothrombin time (PT), or factor (F) VII, FVIII, FXII or D-dimers. Residential distance to a major road was only marginally correlated with procoagulant changes in FVIII and thrombin generation. Conclusions: Increases in the number of microvesicles and in their procoagulant properties, rather than increases in coagulation factors per se, seem to contribute to the risk of VTE, developing during prolonged exposure to air pollutants.
ISSN: 1538-7933
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Public Health miscellaneous
Molecular and Vascular Biology
Leuven Centre for Global Governance Studies
Clinical and Experimental Endocrinology
Occupational, Environmental and Insurance Medicine (-)
Hypertension and Cardiovascular Epidemiology
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science