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Title: Oligofructose and inulin modulate glucose and amino acid metabolism through propionate production in normal-weight and obese cats
Authors: Verbrugghe, Adronie ×
Hesta, Myriam
Gommeren, Kris
Daminet, Sylvie
Wuyts, Birgitte
Buyse, Johan
Janssens, Geert P. J #
Issue Date: Sep-2009
Publisher: CABI Pub.
Series Title: British Journal of Nutrition vol:102 issue:5 pages:694-702
Abstract: The effect of dietary oligofructose and inulin supplementation on glucose metabolism in obese and non-obese cats was assessed. Two diets were tested in a crossover design; a control diet high in protein (46% on DM basis), moderate in fat (15%), low in carbohydrates (27%), but no soluble fibres added; and a prebiotic diet, with 2.5% of a mixture of oligofructose and inulin added to the control diet. Eight non-obese and eight obese cats were allotted to each of two diets in random order at intervals of 4 weeks. At the end of each testing period, intravenous glucose tolerance tests were performed. Area under the glucose curve (AUC(gluc)) was increased (P=0.022) and the second insulin peak was delayed (P=0.009) in obese compared to non-obese cats. Diets did not affect fasting plasma glucose concentrations, blood glucose response at each glucose time-point after glucose administration, AUC(gluc), fasting serum insulin concentrations, area under the insulin curve, and height and appearance time of insulin response. Yet, analysis of acylcarnitines revealed higher propionylcarnitine concentrations (P=0.03) when fed the prebiotic diet, suggesting colonic fermentation and propionate absorption. Prebiotic supplementation reduced methylmalonylcarnitine (P=0.072) and aspartate aminotransferase concentrations (P=0.025), both indicating reduced gluconeogenesis from amino acids. This trial evidenced impaired glucose tolerance and altered insulin response to glucose administration in obese compared to non-obese cats, regardless of dietary intervention; yet modulation of glucose metabolism by enhancing gluconeogenesis from propionate and inhibition of amino acid catabolism can be suggested.
ISSN: 0007-1145
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Division of Livestock-Nutrition-Quality (-)
× corresponding author
# (joint) last author

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