Title: Synthesis and in-vitro biodegradation of poly(ether-ester) azo polymers designed for colon targeting
Authors: Samyn, Celest ×
Kalala, W
Van den Mooter, Guy
Kinget, Renaat #
Issue Date: Jul-1995
Publisher: Elsevier science bv
Series Title: International journal of pharmaceutics vol:121 issue:2 pages:211-216
Abstract: A number of poly(ether-ester) azo polymers consisting of various concentrations of 4-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}benzoic acid (HEEEBA), 4-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}phenylaozobenzoic acid (HEEEPABA) and either 12-hydroxydodecanoic or 16-hydroxyhexadecanoic acid were synthesized. The polymers were assessed in order to determine whether they are biodegradable by the azoreductase present in the rat caecum. The polymers containing HEEEBA showed satisfactory degradation (up to 48%), while those without showed poor degradation, due to poor wettability. When 1% polysorbate 80 (a wetting agent) was added to the polymers in the degradation medium, all polymers showed excellent degradation. Azo polymers with HEEEBA have the potential to be used as colon-specific drug release materials.
ISSN: 0378-5173
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Drug Delivery and Disposition
Chemistry - miscellaneous
× corresponding author
# (joint) last author

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