Title: Activation of the cold-sensing TRPM8 channel triggers UCP1-dependent thermogenesis and prevents obesity
Authors: Yu, Hao ×
Zhao, Zhigang
Luo, Zhidan
Chen, Jing
Ni, Yinxing
Jin, Rongbing
Wang, Peijian
Zhu, Zhenyu
Zhong, Jian
Liu, Daoyan
Nilius, Bernd
Zhu, Zhiming #
Issue Date: Apr-2012
Series Title: Journal of Molecular Cell Biology vol:4 issue:2 pages:88-96
Abstract: Brown adipose tissue (BAT) is an energy-expending organ that produces heat. Expansion or activation of BAT prevents obesity and diabetes. Chronic cold exposure enhances thermogenesis in BAT through uncoupling protein 1 (UCP1) activation triggered via a β-adrenergic pathway. Here, we report that the cold-sensing transient receptor potential melastatin 8 (TRPM8) is functionally present in mouse BAT. Challenging brown adipocytes with menthol, a TRPM8 agonist, up-regulates UCP1 expression and requires protein kinase A activation. Upon mimicking long-term cold exposure with chronic dietary menthol application, menthol significantly increased the core temperatures and locomotor activity in wild-type mice; these effects were absent in both TRPM8(-/-) and UCP1(-/-) mice. Dietary obesity and glucose abnormalities were also prevented by menthol treatment. Our results reveal a previously unrecognised role for TRPM8, suggesting that stimulation of this channel mediates BAT thermogenesis, which could constitute a promising way to treat obesity.
ISSN: 1674-2788
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Cellular and Molecular Medicine - miscellaneous
× corresponding author
# (joint) last author

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