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Title: Development of a New Tool for 3D Modeling for Regenerative Medicine
Authors: Mattoli, Filippo ×
Tiribuzi, Roberto
D'Angelo, Francesco
di Girolamo, Ilaria
Quattrocelli, Mattia
Montesano, Simona
Crispoltoni, Lucia
Oikonomou, Vasileios
Cusella De Angelis, Maria Gabriella
Marconi, Peggy
Orlacchio, Antonio
Sampaolesi, Maurilio
Martino, Sabata
Orlacchio, Aldo #
Issue Date: 2011
Publisher: Hindawi Pub. Corp.
Series Title: International Journal of Biomedical Imaging vol:2011 pages:236854
Abstract: The effectiveness of therapeutic treatment based on regenerative medicine for degenerative diseases (i.e., neurodegenerative or cardiac diseases) requires tools allowing the visualization and analysis of the three-dimensional (3D) distribution of target drugs within the tissue. Here, we present a new computational procedure able to overcome the limitations of visual analysis emerging by the examination of a molecular signal within images of serial tissue/organ sections by using the conventional techniques. Together with the 3D anatomical reconstitution of the tissue/organ, our framework allows the detection of signals of different origins (e.g., marked generic molecules, colorimetric, or fluorimetric substrates for enzymes; microRNA; recombinant protein). Remarkably, the application does not require the employment of specific tracking reagents for the imaging analysis. We report two different representative applications: the first shows the reconstruction of a 3D model of mouse brain with the analysis of the distribution of the β-Galactosidase, the second shows the reconstruction of a 3D mouse heart with the measurement of the cardiac volume.
URI: 
ISSN: 1687-4188
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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