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Title: Synthesis of Isoquinolinium-2-yl Amides via Silver(I)-Catalyzed Ring Closure of N '-(2-Alkynylbenzylidene)hydrazides
Authors: Peshkov, Vsevolod A ×
Pereshivko, Olga P
Van Hove, Sofie
Ermolat'ev, Denis S
Van der Eycken, Erik #
Issue Date: Oct-2011
Publisher: Thieme Chemistry
Series Title: Synthesis issue:20 pages:3371-3374
Abstract: An efficient one-pot protocol for the synthesis of isoquinolinium- 2-yl amides starting from readily available hydrazides and 2-alkynylbenzaldehydes is described. The key step of the protocol is a silver(I)-catalyzed ring-closure of N'-(2-alkynylbenzylidene)hydrazides that are generated in situ. Isoquinolinium-2-yl amides derived from tert-butoxycarbonyl hydrazide could be further deprotected, delivering 2-aminoisoquinolinium trifluoroacetates.
ISSN: 0039-7881
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Design and Synthesis
× corresponding author
# (joint) last author

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