Title: Synthesis and biological activity evaluation of N-protected isatin derivatives as inhibitors of ICAM-1 expression on human endothelial cells
Authors: Malhotra, Shashwat ×
Balwani, Sakshi
Dhawan, Ashish
Singh, Brajendra K
Kumar, Sarvesh
Thimmulappa, Rajesh
Biswal, Shyam
Olsen, Carl E
Van der Eycken, Erik
Prasad, Ashok K
Ghosh, Balaram
Parmar, Virinder S #
Issue Date: Aug-2011
Publisher: Royal Society of Chemistry
Series Title: Medicinal Chemistry Communications vol:2 issue:8 pages:743-751
Abstract: Novel N-protected derivatives of substituted isatins have been synthesized and evaluated for their potency in inhibiting TNF-alpha-induced ICAM-1 activity on human endothelial cells as a marker for anti-inflammatory activity. Compound 3p was found to be most potent in inhibiting the ICAM-1 expression in a concentration- and time-dependent manner. The structure-activity relationship of these compounds in inhibiting ICAM-1 expression activity is elucidated in the present study.
ISSN: 2040-2503
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Design and Synthesis
× corresponding author
# (joint) last author

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