Title: A role for myelin-associated peroxisomes in maintaining paranodal loops and axonal integrity
Authors: Kassmann, Celia M ×
Quintes, Susanne
Rietdorf, Jens
Moebius, Wiebke
Sereda, Michael Werner
Nientiedt, Tobias
Saher, Gesine
Baes, Myriam
Nave, Klaus-Armin #
Issue Date: Jul-2011
Publisher: Elsevier on behalf of the Federation of European Biochemical Societies
Series Title: FEBS Letters vol:585 issue:14 pages:2205-2211
Abstract: Demyelinating diseases of the nervous system cause axon loss but the underlying mechanisms are not well understood. Here we show by confocal and electron microscopy that in myelin-forming glia peroxisomes are associated with myelin membranes. When peroxisome biogenesis is experimentally perturbed in Pex5 conditional mouse mutants, myelination by Schwann cells appears initially normal. However, in nerves of older mice paranodal loops become physically unstable and develop swellings filled with vesicles and electron-dense material. This novel model of a demyelinating neuropathy demonstrates that peroxisomes serve an important function in the peripheral myelin compartment, required for long-term axonal integrity. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
ISSN: 0014-5793
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Cell Metabolism
× corresponding author
# (joint) last author

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