A role for myelin-associated peroxisomes in maintaining paranodal loops and axonal integrity
Kassmann, Celia M × Quintes, Susanne Rietdorf, Jens Moebius, Wiebke Sereda, Michael Werner Nientiedt, Tobias Saher, Gesine Baes, Myriam Nave, Klaus-Armin #
Elsevier on behalf of the Federation of European Biochemical Societies
FEBS Letters vol:585 issue:14 pages:2205-2211
Demyelinating diseases of the nervous system cause axon loss but the underlying mechanisms are not well understood. Here we show by confocal and electron microscopy that in myelin-forming glia peroxisomes are associated with myelin membranes. When peroxisome biogenesis is experimentally perturbed in Pex5 conditional mouse mutants, myelination by Schwann cells appears initially normal. However, in nerves of older mice paranodal loops become physically unstable and develop swellings filled with vesicles and electron-dense material. This novel model of a demyelinating neuropathy demonstrates that peroxisomes serve an important function in the peripheral myelin compartment, required for long-term axonal integrity. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.