Title: A novel application of hybrid two-dimensional correlation infrared spectroscopy: Exploration of the reversibility of the pressure- and temperature-induced phase separation of poly(N-isopropylacrylamide) and poly(N-isopropylmethacrylamide) in aqueous solution
Authors: Wu, YQ ×
Meersman, Filip
Ozaki, Y #
Issue Date: Jan-2006
Publisher: Amer chemical soc
Series Title: Macromolecules vol:39 issue:3 pages:1182-1188
Abstract: We have demonstrated a novel application of hybrid two-dimensional (2D) correlation spectroscopy in exploring the reversibility of phase separation (or transitions). Pressure-induced phase separation and temperature-induced phase transitions have been studied for poly (N-isopropylacrylamide) (PNiPA) and poly(N-isopropylmethacrylamide) (PNiPMA) in aqueous solutions using Fourier transform infrared (IR) and hybrid 2D correlation spectroscopy. Here we show that pressure-dependent sample-sample (SS) hybrid 2D correlation IR spectroscopy reveals for PNiPA a reversible phase separation with a differential rate of concentration change and separation pressure and a reversible phase separation with similar dynamics for PNiPMA, but involving irreversible hydrogen/deuterium exchange. Subtle differences in concentration dynamics have been revealed clearly by the hybrid SS 2D IR correlation analysis; these include the minor irreversibility of amide I in PNiPA, resulting from the loss of a very few coil populations, and in PNiPMA, resulting from the irreversible HID exchange. Such events are not apparent from the transition plots constructed on the basis of one-dimensional data analysis.
ISSN: 0024-9297
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Imaging and Photonics
× corresponding author
# (joint) last author

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