Title: Fiber optic high-resolution genetic screening using gold-labeled gene probes
Authors: Knez, Karel
Janssen, Kris
Pollet, Jeroen
Spasic, Dragana
Lammertyn, Jeroen # ×
Issue Date: Mar-2012
Publisher: Wiley
Series Title: Small vol:8 issue:6 pages:868-872
Abstract: A new, ultra-sensitive genetic screening tool based on a fiber-optic (FO) surface plasmon biosensor and gold-labeled gene probes is presented. The assay allows for the detection and location of single point mutations (SNP) at significantly reduced cost and high speed. We illustrate the principle and evaluate the assay for SNP detection in 3 different DNA targets, including a GC rich cancer gene fragment and a long bacterial sequence. The data proves that the accuracy of the FO-SNP test is as good or, in some applications, better than classical HRM.
ISSN: 1613-6810
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Division of Mechatronics, Biostatistics and Sensors (MeBioS)
× corresponding author
# (joint) last author

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