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Title: Design and synthesis of novel type VI-like beta-turn mimetics. Diversity at the i+1 and the i+2 position
Authors: De Borggraeve, Wim ×
Verbist, BMP
Rombouts, FJR
Pawar, Vijaykumar
Smets, WJ
Kamoune, Laïla
Alen, Jo
Van der Eycken, Erik
Compernolle, Frans
Hoornaert, GJ #
Issue Date: Jan-2004
Publisher: Pergamon-elsevier science ltd
Series Title: Tetrahedron vol:60 issue:50 pages:11597-11612
Abstract: In this paper, a synthetic approach for functionalised 5-aminopiperidinone-2-carboxylate (APC) systems as non-pro cis-peptide bond containing external beta-turn mimics is presented. The scope and limitations of the synthetic method are discussed and the potential turn inducing properties of a model compound are evaluated by means of molecular modelling and NMR analysis. (C) 2004 Elsevier Ltd. All rights reserved.
ISSN: 0040-4020
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Design and Synthesis
Chemistry - miscellaneous
× corresponding author
# (joint) last author

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