Title: The long-term outcome of patients with polycystic liver disease treated with lanreotide
Authors: Chrispijn, M ×
Nevens, Frederik
Gevers, T J G
Vanslembrouck, Ragna
van Oijen, M G H
Coudyzer, W
Hoffmann, A L
Dekker, H M
de Man, R A
van Keimpema, L
Drenth, J P H #
Issue Date: Jan-2012
Publisher: Blackwell Science
Series Title: Alimentary Pharmacology & Therapeutics vol:35 issue:2 pages:266-274
Article number: 10.1111/j.1365-2036.2011.04923.x
Abstract: Aliment Pharmacol Ther 2012; 35: 266-274 SUMMARY: Background  Polycystic liver disease (PLD) is a phenotypical expression of autosomal dominant polycystic kidney disease and isolated polycystic liver disease. Somatostatin analogues, such as lanreotide, reduce polycystic liver volume. Aim  To establish long-term outcome and safety of lanreotide. Methods  This was an open-label, observational extension study of a 6-month, randomised, placebo-controlled trial with lanreotide (120 mg/month) in PLD. The length of total treatment was 12 months. Primary endpoint was relative change in liver volume, as determined by CT-volumetry after 12 months of treatment. We offered patients a CT scan 6 months after stopping lanreotide. Results  A total of 41/54 (76%) patients participated in the extension study. Liver volume decreased by 4% (IQR -8% to -1%) after 12 months of treatment. The greatest effect was observed during the first 6 months of treatment (decrease of 4% (IQR -6% to -1%)). Liver volume remained unchanged during the following 6 months. We found that liver volume increased by 4% (IQR 0-6%) 6 months after end of treatment (n = 22). Conclusions  Lanreotide reduces liver volume within the first 6 months of treatment and the beneficial effect is maintained in the following 6 months. Stopping results in recurrence of polycystic liver growth. This suggests that continuous use of lanreotide is needed to maintain its effect.
ISSN: 0269-2813
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Hepatology
× corresponding author
# (joint) last author

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