Title: Androgens and skeletal muscle: cellular and molecular action mechanisms underlying the anabolic actions
Authors: Dubois, Vanessa ×
Laurent, Michaël
Boonen, Steven
Vanderschueren, Dirk
Claessens, Frank #
Issue Date: May-2012
Publisher: Birkhäuser Verlag
Series Title: Cellular and Molecular Life Sciences vol:69 issue:10 pages:1651-1667
Abstract: Androgens increase both the size and strength of skeletal muscle via diverse mechanisms. The aim of this review is to discuss the different cellular targets of androgens in skeletal muscle as well as the respective androgen actions in these cells leading to changes in proliferation, myogenic differentiation, and protein metabolism. Androgens bind and activate a specific nuclear receptor which will directly affect the transcription of target genes. These genes encode muscle-specific transcription factors, enzymes, structural proteins, as well as microRNAs. In addition, anabolic action of androgens is partly established through crosstalk with other signaling molecules such as Akt, myostatin, IGF-I, and Notch. Finally, androgens may also exert non-genomic effects in muscle by increasing Ca(2+) uptake and modulating kinase activities. In conclusion, the anabolic effect of androgens on skeletal muscle is not only explained by activation of the myocyte androgen receptor but is also the combined result of many genomic and non-genomic actions.
ISSN: 1420-682X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical and Experimental Endocrinology
Laboratory of Molecular Endocrinology
Gerontology and Geriatrics
× corresponding author
# (joint) last author

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