Title: Characterization of colon-specific azo polymers - a study of the swelling properties and the permeability of isolated polymer-films
Authors: Van den Mooter, Guy ×
Samyn, Celest
Kinget, Renaat #
Issue Date: Oct-1994
Publisher: Elsevier science bv
Series Title: International journal of pharmaceutics vol:111 issue:2 pages:127-136
Abstract: In order to prepare azo polymers for colonic targeting, copolymers of 2-hydroxyethyl methacrylate (HEMA) and methyl methacrylate (MMA), and terpolymers of HEMA, MMA, and methacrylic acid (MA) were-synthesized in the presence of different azo compounds. In the present study, the azo polymers were characterized by swelling and permeability studies, performed on isolated films. It was shown that MMA is the swelling capacity and rate determining compound in the azo polymers investigated. Permeability experiments revealed that the diffusion of caffeine as well as the transmission of water vapour is proportional to the concentration of HEMA in the polymers. Hydrophilic plasticizers increase water vapour transmission and diffusion of caffeine through the films. By incorporation of MA into the azo polymers, pH dependency was introduced. The swelling behaviour and diffusion of caffeine are nearly constant over the pH range from 1 to 6. A sharp increase above pH 6, corresponding with the ionization of the carboxylic acid groups appears, with a maximum around pH 8.
ISSN: 0378-5173
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Drug Delivery and Disposition
Chemistry - miscellaneous
× corresponding author
# (joint) last author

Files in This Item:
File Description Status SizeFormat
1994-Van den Mooter-Characterization of colon-specific azo polymers...- Int J Pharmaceut.pdf Published 2130KbAdobe PDFView/Open Request a copy

These files are only available to some KU Leuven Association staff members


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science