Title: Impact of conjugate 7-valent vaccination in Belgium: addressing methodological challenges
Authors: Hanquet, Germaine ×
Lernout, Tinne
Vergison, Anne
Verhaegen, Jan
Kissling, Esther
Tuerlinckx, David
Malfroot, Anne
Swennen, Béatrice
Sabbe, Martine
Proesmans, Marijke
Belgian IPD Scientific Committee #
Issue Date: Apr-2011
Publisher: Butterworths
Series Title: Vaccine vol:29 issue:16 pages:2856-2864
Abstract: In Belgium, the 7-valent pneumococcal conjugate vaccine (PCV7) was introduced into the national schedule in 2007. The early impact of PCV7 vaccination on paediatric invasive disease was estimated by comparing pre- and post-vaccination incidence from national surveillance. In children <2 year-olds, vaccine-serotype incidence declined by 96% but non-vaccine-types increased 2-3-fold. Overall invasive disease decreased by 23-46%, depending on adjustment for under-reporting and pre-vaccine trends. Non-vaccine-types 1 and 19A had increased before PCV7 use, suggesting the contribution of other factors. Estimation of PCV7 impact comparing pre- and post-vaccination data should adjust for pre-vaccine trends, and serotype dynamics need further exploration.
ISSN: 0264-410X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Clinical Bacteriology and Mycology
Faculty of Kinesiology and Rehabilitation Sciences - miscellaneous
Pediatric Pulmonology Section (-)
× corresponding author
# (joint) last author

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