Exacerbation of cigarette smoke-induced pulmonary inflammation by Staphylococcus aureus enterotoxin B in mice
Huvenne, Wouter × Lanckacker, Ellen A Krysko, Olga Bracke, Ken R Demoor, Tine Hellings, Peter Brusselle, Guy G Joos, Guy F Bachert, Claus Maes, Tania #
Biomed Central Ltd
Respiratory Research vol:12 pages:69
Cigarette smoke (CS) is a major risk factor for the development of COPD. CS exposure is associated with an increased risk of bacterial colonization and respiratory tract infection, because of suppressed antibacterial activities of the immune system and delayed clearance of microbial agents from the lungs. Colonization with Staphylococcus aureus results in release of virulent enterotoxins, with superantigen activity which causes T cell activation.