Title: Exacerbation of cigarette smoke-induced pulmonary inflammation by Staphylococcus aureus enterotoxin B in mice
Authors: Huvenne, Wouter ×
Lanckacker, Ellen A
Krysko, Olga
Bracke, Ken R
Demoor, Tine
Hellings, Peter
Brusselle, Guy G
Joos, Guy F
Bachert, Claus
Maes, Tania #
Issue Date: May-2011
Publisher: Biomed Central Ltd
Series Title: Respiratory Research vol:12 pages:69
Abstract: Cigarette smoke (CS) is a major risk factor for the development of COPD. CS exposure is associated with an increased risk of bacterial colonization and respiratory tract infection, because of suppressed antibacterial activities of the immune system and delayed clearance of microbial agents from the lungs. Colonization with Staphylococcus aureus results in release of virulent enterotoxins, with superantigen activity which causes T cell activation.
ISSN: 1465-993X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Research Group Experimental Oto-rhino-laryngology
Laboratory of Clinical Immunology
× corresponding author
# (joint) last author

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