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Title: From aggregation to chaperoning: Pressure effect on intermolecular interactions of proteins
Authors: Smeller, L ×
Meersman, Filip
Tolgyesi, F
Bode, C
Fidy, J
Heremans, Karel #
Issue Date: Jan-2002
Publisher: Taylor & francis ltd
Series Title: High pressure research vol:22 issue:3-4 pages:751-756
Abstract: The effect of pressure on the protein aggregation is shown in this paper. Deposition of insoluble protein aggregates is one of the key factors in the conformational diseases. Pressure counteracts the formation of intermolecular beta-structure. Already slight pressurization to typically 2-3kbar can destabilize aggregates of apo-horseradish peroxidase. On the other hand, the chaperone proteins, which prevent aggregation of damaged proteins exist in big oligomers. We show that pressure treatment of these aggregates changes the chaperone activity.
URI: 
ISSN: 0895-7959
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Imaging and Photonics
Biochemistry, Molecular and Structural Biology Section
× corresponding author
# (joint) last author

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