Title: Translational gastrointestinal pharmacology in the 21st century: 'the lesogaberan story'
Authors: Boeckxstaens, Guy ×
Denison, Hans
Jensen, Jörgen M
Lehmann, Anders
Ruth, Magnus #
Issue Date: Dec-2011
Publisher: Elsevier Science Ltd.
Series Title: Current Opinion in Pharmacology vol:11 issue:6 pages:630-633
Abstract: The development of the novel γ-aminobutyric acid type-B receptor (GABA(B)) agonist lesogaberan is presented as an example of a partly successful translational strategy in the field of gastroenterology. Data on transient lower esophageal sphincter relaxations (TLESRs) and gastroesophageal reflux inhibition from preclinical models translated well to clinical studies in healthy volunteers and patients with gastroesophageal reflux disease (GERD). Animal models have also been used successfully to predict the effect of other target mechanisms on TLESRs in humans. However, while translation of physiology to symptomatology in patients with GERD was achieved, the effect size was too small to be of clinical significance. A deeper understanding of the cause of symptoms in different patient categories is therefore required.
ISSN: 1471-4892
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Research in GastroIntestinal Disorders
× corresponding author
# (joint) last author

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