Title: Stereoselective transformation of 2H-1,4-oxazin-2-ones into 2,(2),5,5-tri- and tetrasubstituted analogues of cis-5-hydroxy-2-piperidinemethanol and cis-5-hydroxy-6-oxo-2-piperidinecarboxyl acid
Authors: Wu, XJ ×
Dubois, K
Rogiers, Joeri
Toppet, Suzanne
Compernolle, Frans
Hoornaert, GJ #
Issue Date: Jan-2000
Publisher: Pergamon-elsevier science ltd
Series Title: Tetrahedron vol:56 issue:19 pages:3043-3051
Abstract: 2,(2),5,5-Tri- and tetrasubstituted analogues of 5-hydroxy-2-piperidinemethanol and 5-hydroxy-6-oxo-2-piperidinecarboxylic acid have been prepared via Diels-Alder reaction of 3-substituted 2H-1,4-oxazin-2-ones with ethene followed by functional group transformation of the resulting imidoyl chloride and lactone groups. Some of the 2-piperidinemethanol products are converted further into potential substance P antagonists. (C) 2000 Elsevier Science Ltd. All rights reserved.
ISSN: 0040-4020
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Design and Synthesis
Theoretical Physics Section
× corresponding author
# (joint) last author

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