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Title: Correctly validating results from single molecule data: The case of stretched exponential decay in the catalytic activity of single lipase B molecules
Authors: Flomenbom, Ophir ×
Hofkens, Johan
Velonia, Kelly
De Schryver, Frans
Rowan, Alan E
Nolte, Roeland J. M
Klafter, Joseph
Silbey, Robert J #
Issue Date: Dec-2006
Publisher: Elsevier
Series Title: Chemical Physics Letters vol:432 issue:1-3 pages:371-374
Abstract: The question of how to validate and interpret correctly the waiting time probability density functions (WT-PDFs) from single molecule data is addressed. It is shown by simulation that when a stretched exponential WT-PDF, phi(off) (t) = phi(0)e(-(iota/tau)alpha), generates the off periods of a two-state trajectory, a reliable recovery of the input phi(off)(t) from the trajectory is obtained even when the bin size used to define the trajectory, dt, is much larger than the parameter tau. This holds true as long as the first moment of the WT-PDF is much larger than dt. Our results validate the results in an earlier study of the activity of single lipase B molecules and disprove recent related critique. (c) 2006 Elsevier B.V. All rights reserved.
URI: 
ISSN: 0009-2614
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Imaging and Photonics
× corresponding author
# (joint) last author

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