Title: Investigation of the cytotoxicity of nanozeolites A and Y
Authors: Thomassen, Leen * ×
Napierska, Dorota *
Dinsdale, David
Lievens, Nele
Jammaer, Jasper
Lison, Dominique
Kirschhock, Christine
Hoet, Peter
Martens, Johan #
Issue Date: Aug-2012
Publisher: Informa Healthcare
Series Title: Nanotoxicology vol:6 issue:5 pages:472-485
Abstract: Abstract Nanosized zeolite particles are important materials for many applications in the field of nanotechnology. The possible adverse effects of these nanomaterials on human health have been scarcely investigated and remain largely unknown. This study reports the synthesis of nanozeolites Y and A with particle sizes of 25-100 nm and adequate colloidal stability for in vitro cytotoxicity experiments. The cytotoxic response of macrophages, epithelial and endothelial cells to these nanocrystals was assessed by determining mitochondrial activity (MTT assay) and cell membrane integrity (LDH leakage assay). After 24 h of exposure, no significant cytotoxic activity was detected for nanozeolite doses up to 500 μg/ml. The addition of fetal calf serum to the cell culture medium during exposure did not significantly change this low response. The nanozeolites showed low toxicity compared with monodisperse amorphous silica nanoparticles of similar size (60 nm). These results may contribute to the application of safe nanozeolites for purposes such as medical imaging, sensing materials, low-k films and molecular separation processes.
ISSN: 1743-5390
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Environment and Health - miscellaneous
Centre for Surface Chemistry and Catalysis
Occupational, Environmental and Insurance Medicine (-)
Formerly "Departement Industriƫle Wetenschappen - TM M"
Microbial and Molecular Systems - miscellaneous
* (joint) first author
× corresponding author
# (joint) last author

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