Title: ELP3 Controls Active Zone Morphology by Acetylating the ELKS Family Member Bruchpilot
Authors: Miskiewicz, Katarzyna
Jose, Liya
Bento-Abreu, André
Fislage, Marcus
Taes, Ines
Kasprowicz, Jaroslaw
Swerts, Jef
Sigrist, Stephan
Versées, Wim
Robberecht, Wim
Verstreken, Patrik # ×
Issue Date: 8-Dec-2011
Publisher: Cell Press
Series Title: Neuron vol:72 issue:5 pages:776-788
Abstract: Elongator protein 3 (ELP3) acetylates histones in the nucleus but also plays a role in the cytoplasm. Here, we report that in Drosophila neurons, ELP3 is necessary and sufficient to acetylate the ELKS family member Bruchpilot, an integral component of the presynaptic density where neurotransmitters are released. We find that in elp3 mutants, presynaptic densities assemble normally, but they show morphological defects such that their cytoplasmic extensions cover a larger area, resulting in increased vesicle tethering as well as a more proficient neurotransmitter release. We propose a model where ELP3-dependent acetylation of Bruchpilot at synapses regulates the structure of individual presynaptic densities and neurotransmitter release efficiency.
ISSN: 0896-6273
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
Laboratory of Neuronal Communication
Research Group Experimental Neurology
Laboratory for Neurobiology (Vesalius Research Center)
× corresponding author
# (joint) last author

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