ITEM METADATA RECORD
Title: Synaptic vesicle trafficking and Parkinson's disease
Authors: Esposito, Giovanni ×
Dos Santos Oliveira Fernandes, Ana Clara
Verstreken, Patrik #
Issue Date: Jan-2012
Publisher: John Wiley & Sons, Inc.
Series Title: Developmental Neurobiology vol:72 issue:1 pages:134-144
Article number: 10.1002/dneu.20916
Abstract: Presynaptic terminals maintain neurotransmitter release during repeated rounds of stimulation using local recycling of synaptic vesicles. During each synaptic vesicle cycle, protein complex assembly and disassembly results in accumulation of inactive (unfolded) protein intermediates that may render synaptic terminals vulnerable to activity-dependent degeneration. Synaptic vesicle trafficking is affected in many neurodegenerative conditions including Alzheimer' and Parkinson's disease suggesting that alteration of this process might be an important aspect of disease pathogenesis. This article reviews our current understanding for a role of causative Parkinson's disease genes in the synaptic vesicle cycle and speculates on the potential role of aberrant synaptic vesicle trafficking in the neurodegenerative cascade of Parkinson's disease. © 2011 Wiley Periodicals, Inc. Develop Neurobiol, 2011.
URI: 
ISSN: 1932-8451
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
Laboratory of Neuronal Communication
× corresponding author
# (joint) last author

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