The importance of appropriate partial volume correction for PET quantification in Alzheimer's disease
Thomas, Benjamin A × Erlandsson, Kjell Modat, Marc Thurfjell, Lennart Vandenberghe, Rik Ourselin, Sebastien Hutton, Brian F #
European Journal of Nuclear Medicine and Molecular Imaging vol:38 issue:6 pages:1104-1119
Alzheimer's disease (AD) is the most common form of dementia. Clinically, it is characterized by progressive cognitive and functional impairment with structural hallmarks of cortical atrophy and ventricular expansion. Amyloid plaque aggregation is also known to occur in AD subjects. In-vivo imaging of amyloid plaques is now possible with positron emission tomography (PET) radioligands. PET imaging suffers from a degrading phenomenon known as the partial volume effect (PVE). The quantitative accuracy of PET images is reduced by PVEs primarily due to the limited spatial resolution of the scanner. The degree of PVE is influenced by structure size, with smaller structures tending to suffer from more severe PVEs such as atrophied grey matter regions. The aims of this paper were to investigate the effect of partial volume correction (PVC) on the quantification of amyloid PET and to highlight the importance of selecting an appropriate PVC technique.