Preparation and physicochemical characterization of biodegradable nerve guides containing the nerve growth agent sabeluzole
Verreck, G Chun, IK Li, YF Kataria, R Zhang, Qi Rosenblatt, J Decorte, A Heymans, K Adriaensen, J Bruining, M Van Remoortere, M Borghys, H Meert, Theo Peeters, J Brewster, ME #
Elsevier sci ltd
Biomaterials vol:26 issue:11 pages:1307-1315
The objective of this study was to develop and characterize a biodegradable drug-loaded nerve guide for peripheral nerve regeneration. Sabeluzole, a nerve growth agent, was selected as model compound. Four biodegradable polymers were selected for this study: a copolymer of polylactic acid and polycaprolactone (PCL); a copolymer of polyglycolic acid and polycaprolactone PCL; a copolymer of PCL/polydioxanone (PDO) and PDO. Placebo and drug loaded nerve guides were obtained by melt compression and melt extrusion.