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Title: Preparation and physicochemical characterization of biodegradable nerve guides containing the nerve growth agent sabeluzole
Authors: Verreck, G
Chun, IK
Li, YF
Kataria, R
Zhang, Qi
Rosenblatt, J
Decorte, A
Heymans, K
Adriaensen, J
Bruining, M
Van Remoortere, M
Borghys, H
Meert, Theo
Peeters, J
Brewster, ME #
Issue Date: Jan-2005
Publisher: Elsevier sci ltd
Series Title: Biomaterials vol:26 issue:11 pages:1307-1315
Abstract: The objective of this study was to develop and characterize a biodegradable drug-loaded nerve guide for peripheral nerve regeneration. Sabeluzole, a nerve growth agent, was selected as model compound. Four biodegradable polymers were selected for this study: a copolymer of polylactic acid and polycaprolactone (PCL); a copolymer of polyglycolic acid and polycaprolactone PCL; a copolymer of PCL/polydioxanone (PDO) and PDO. Placebo and drug loaded nerve guides were obtained by melt compression and melt extrusion.
URI: 
ISSN: 0142-9612
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
# (joint) last author

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