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Title: The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a-mediated suppression of interferon alpha receptor
Authors: Papadopoulou, Smaragda *
Dooley, James *
Linterman, Michelle
Pierson, Wim
Ucar, Olga
Kyewski, Bruno
Zuklys, Saulius
Hollander, Georg
Matthys, Patrick
Gray, Daniel
De Strooper, Bart
Liston, Adrian # ×
Issue Date: Feb-2012
Publisher: Nature America Inc.
Series Title: Nature Immunology vol:13 issue:2 pages:181-187
Abstract: Thymic output is a dynamic process, with high activity at birth punctuated by transient periods of involution during infection. Interferon-α (IFN-α) is a critical molecular mediator of pathogen-induced thymic involution, yet despite the importance of thymic involution, relatively little is known about the molecular integrators that establish sensitivity. Here we found that the microRNA network dependent on the endoribonuclease Dicer, and specifically microRNA miR-29a, was critical for diminishing the sensitivity of the thymic epithelium to simulated infection signals, protecting the thymus against inappropriate involution. In the absence of Dicer or the miR-29a cluster in the thymic epithelium, expression of the IFN-α receptor by the thymic epithelium was higher, which allowed suboptimal signals to trigger rapid loss of thymic cellularity.
ISSN: 1529-2908
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Genetics of Autoimmunity
Laboratory for the Research of Neurodegenerative Diseases
Laboratory of Immunobiology (Rega Institute)
Department of Human Genetics - miscellaneous
* (joint) first author
× corresponding author
# (joint) last author

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