Title: Proper synaptic vesicle formation and neuronal network activity critically rely on syndapin I
Authors: Koch, Dennis ×
Spiwoks-Becker, Isabella
Sabanov, Victor
Sinning, Anne
Dugladze, Tamar
Stellmacher, Anne
Ahuja, Rashmi
Grimm, Julia
Schüler, Susann
Müller, Anke
Angenstein, Frank
Ahmed, Tariq
Diesler, Alexander
Moser, Markus
Tom Dieck, Susanne
Spessert, Rainer
Boeckers, Tobias Maria
Fässler, Reinhard
Hübner, Christian Andreas
Balschun, Detlef
Gloveli, Tengis
Kessels, Michael Manfred
Qualmann, Britta #
Issue Date: Dec-2011
Publisher: Nature Publishing Group
Series Title: EMBO Journal vol:30 issue:24 pages:4955-4969
Abstract: Synaptic transmission relies on effective and accurate compensatory endocytosis. F-BAR proteins may serve as membrane curvature sensors and/or inducers and thereby support membrane remodelling processes; yet, their in vivo functions urgently await disclosure. We demonstrate that the F-BAR protein syndapin I is crucial for proper brain function. Syndapin I knockout (KO) mice suffer from seizures, a phenotype consistent with excessive hippocampal network activity. Loss of syndapin I causes defects in presynaptic membrane trafficking processes, which are especially evident under high-capacity retrieval conditions, accumulation of endocytic intermediates, loss of synaptic vesicle (SV) size control, impaired activity-dependent SV retrieval and defective synaptic activity. Detailed molecular analyses demonstrate that syndapin I plays an important role in the recruitment of all dynamin isoforms, central players in vesicle fission reactions, to the membrane. Consistently, syndapin I KO mice share phenotypes with dynamin I KO mice, whereas their seizure phenotype is very reminiscent of fitful mice expressing a mutant dynamin. Thus, syndapin I acts as pivotal membrane anchoring factor for dynamins during regeneration of SVs.
ISSN: 0261-4189
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory for Biological Psychology
× corresponding author
# (joint) last author

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