Quantification of PCDD/Fs and dioxin-like PCBs in small amounts of human serum using the sensitive H1L7.5c1 mouse hepatoma cell line: Optimization and analysis of human serum samples from adolescents of the Flemish human biomonitoring program FLEHS II
Croes, K × Van Langenhove, K Den Hond, E Bruckers, L Colles, A Koppen, G Loots, I Nelen, Veerle Schoeters, G Nawrot, Tim Van Larebeke, N Denison, M. S Vandermarken, T Elskens, Marc Baeyens, W #
Talanta vol:85 issue:5 pages:2484-2491
Since the CALUX (Chemically Activated LUciferase gene eXpression) bioassay is a fast and inexpensive tool for the throughput analysis of dioxin-like compounds in a large number of samples and requires only small sample volumes, the use of this technique in human biomonitoring programs provides a good alternative to GC-HRMS. In this study, a method for the separate analysis of PCDD/Fs and dioxin-like PCBs (dl-PCBs) in human serum with the new sensitive H1L7.5c1 mouse hepatoma cell line was optimized.