Overexpression of caveolin-1 and -2 in cell lines and in human samples of inflammatory breast cancer
Van den Eynden, Gert G × Van Laere, Steven Van der Auwera, Ilse Merajver, Sofia D Van Marck, Eric A van Dam, Peter Vermeulen, Peter B Dirix, Luc Y van Golen, Kenneth L #
Breast Cancer Research and Treatment vol:95 issue:3 pages:219-28
Inflammatory breast cancer (IBC) is the most aggressive form of locally advanced breast cancer (LABC). The IBC phenotype is characterized by an infiltrative growth pattern, increased (lymph)angiogenesis and the propensity to invade dermal lymphatics. In pancreatic cancer, interactions between caveolin-1 and RhoC GTPase, a key molecule in causing the IBC phenotype, regulate tumour cell motility and invasion. In this study we sought to investigate the role of caveolin-1 and -2 in IBC cell lines and in human IBC samples.