Title: Nuclear factor-kappaB signature of inflammatory breast cancer by cDNA microarray validated by quantitative real-time reverse transcription-PCR, immunohistochemistry, and nuclear factor-kappaB DNA-binding
Authors: Van Laere, Steven ×
Van der Auwera, Ilse
Van den Eynden, Gert G
Elst, Hilde J
Weyler, Joost
Harris, Adrian L
van Dam, Peter
Van Marck, Eric A
Vermeulen, Peter B
Dirix, Luc Y #
Issue Date: Jun-2006
Publisher: Association for Cancer Research
Series Title: Clinical Cancer Research vol:12 issue:11 Pt 1 pages:3249-56
Abstract: Inflammatory breast cancer (IBC) is the most aggressive form of locally advanced breast cancer with high metastatic potential. In a previous study, we showed that IBC is a different form of breast cancer compared with non-IBC by cDNA microarray analysis. A list of 756 genes with significant expression differences between IBC and non-IBC was identified. In-depth functional analysis revealed the presence of a high number of nuclear factor-kappaB (NF-kappaB) target genes with elevated expression in IBC versus non-IBC. This led to the hypothesis that NF-kappaB contributes to the phenotype of IBC. The aim of the present study was to further investigate the role of NF-kappaB in IBC.
ISSN: 1078-0432
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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