Array-based DNA methylation profiling for breast cancer subtype discrimination
Van der Auwera, Ilse × Yu, Wayne Suo, Liping Van Neste, Leander van Dam, Peter Van Marck, Eric A Pauwels, Patrick Vermeulen, Peter B Dirix, Luc Y Van Laere, Steven #
Public Library of Sciene
PLoS One vol:5 issue:9 pages:e12616-e12616
Abnormal DNA methylation is well established for breast cancer and contributes to its progression by silencing tumor suppressor genes. DNA methylation profiling platforms might provide an alternative approach to expression microarrays for accurate breast tumor subtyping. We sought to determine whether the distinction of the inflammatory breast cancer (IBC) phenotype from the non-IBC phenotype by transcriptomics could be sustained by methylomics.